BDBM506431 US11045457, Example 141::US11045457, Example 31

SMILES C[C@H]1CN(C)CC[C@@H]1NC(=O)C(C)(C)COc1ncc(C)cc1C

InChI Key InChIKey=OKSHSYZANJEHNU-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 506431   

TargetSomatostatin receptor type 4(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506431(US11045457, Example 141 | US11045457, Example 31)
Affinity DataEC50:  25.1nMAssay Description:This cell-based assay measures the ability of compounds to inhibit forskolin stimulated cAMP in CHO-K1 cells overexpressing SSTR4. CHO-K1 cells overe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506431(US11045457, Example 141 | US11045457, Example 31)
Affinity DataIC50: 251nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506431(US11045457, Example 141 | US11045457, Example 31)
Affinity DataIC50: 1.58E+4nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR1 in membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506431(US11045457, Example 141 | US11045457, Example 31)
Affinity DataEC50:  39.8nMAssay Description:This cell-based assay measures the ability of compounds to inhibit forskolin stimulated cAMP in CHO-K1 cells overexpressing SSTR4. CHO-K1 cells overe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506431(US11045457, Example 141 | US11045457, Example 31)
Affinity DataIC50: 158nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506431(US11045457, Example 141 | US11045457, Example 31)
Affinity DataIC50: 1.00E+4nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR1 in membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent