BDBM506421 US11045457, Example 21

SMILES C[C@H]1CN(C)CC[C@H]1NC(=O)C(C)(C)COc1ncccc1C1CC1

InChI Key InChIKey=CJPRQDWIYBVIQP-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 506421   

TargetSomatostatin receptor type 4(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506421(US11045457, Example 21)
Affinity DataEC50:  25.1nMAssay Description:This cell-based assay measures the ability of compounds to inhibit forskolin stimulated cAMP in CHO-K1 cells overexpressing SSTR4. CHO-K1 cells overe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
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TargetSomatostatin receptor type 4(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506421(US11045457, Example 21)
Affinity DataIC50: 316nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506421(US11045457, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR1 in membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent