BDBM506411 BDBM506506::US11045457, Example 11

SMILES C[C@@H]1CN(C)CC[C@H]1NC(=O)C(C)(C)COc1ncccc1C(F)(F)F

InChI Key InChIKey=HRDHWJSFJWGYQG-UHFFFAOYSA-N

Data  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 506411   

TargetSomatostatin receptor type 4(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506411(US11045457, Example 11 | BDBM506506)
Affinity DataEC50:  10nMAssay Description:This cell-based assay measures the ability of compounds to inhibit forskolin stimulated cAMP in CHO-K1 cells overexpressing SSTR4. CHO-K1 cells overe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506411(US11045457, Example 11 | BDBM506506)
Affinity DataIC50: 100nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506411(US11045457, Example 11 | BDBM506506)
Affinity DataIC50: 7.94E+3nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR1 in membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506411(US11045457, Example 11 | BDBM506506)
Affinity DataEC50:  1.00E+3nMAssay Description:This cell-based assay measures the ability of compounds to inhibit forskolin stimulated cAMP in CHO-K1 cells overexpressing SSTR4. CHO-K1 cells overe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506411(US11045457, Example 11 | BDBM506506)
Affinity DataEC50:  10nMAssay Description:This cell-based assay measures the ability of compounds to inhibit forskolin stimulated cAMP in CHO-K1 cells overexpressing SSTR4. CHO-K1 cells overe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506411(US11045457, Example 11 | BDBM506506)
Affinity DataIC50: 100nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetSomatostatin receptor type 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506411(US11045457, Example 11 | BDBM506506)
Affinity DataIC50: 7.94E+3nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR1 in membranes from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent