BDBM506381 US11045455, Compound 30

SMILES FC(F)(F)CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12

InChI Key InChIKey=KYVZBLQQLBOCDU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 506381   

TargetTyrosine-protein kinase JAK1(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM506381(US11045455, Compound 30)
Affinity DataIC50: 2.22nMAssay Description:1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM506381(US11045455, Compound 30)
Affinity DataIC50: 2.16nMAssay Description:1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM506381(US11045455, Compound 30)
Affinity DataIC50: 36.5nMAssay Description:1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM506381(US11045455, Compound 30)
Affinity DataIC50: 58.2nMAssay Description:1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM506381(US11045455, Compound 30)
Affinity DataIC50: 3.00E+4nMAssay Description:The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent