BDBM50632594 CHEMBL5420349

SMILES COc1cc(Nc2cc(NC(C)=O)ncc2-c2ccc(cn2)C(C)(C)O)nc(c1)S(C)(=O)=O

InChI Key InChIKey=HXQVZOBVKQEION-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50632594   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632594(CHEMBL5420349)
Affinity DataIC50: 0.0270nMAssay Description:Inhibition of TYK2 JH2 (561 to 860 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632594(CHEMBL5420349)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2/TYK2 signal transduction pathway in human NK92 cells assessed as IL-12 induced STAT4 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632594(CHEMBL5420349)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TYK2 signal transduction pathway in human TF-1 cells assessed as reduction in GM-CSF induced p-STAT5 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed