BDBM50632574 CHEMBL5401457

SMILES [2H]C([2H])([2H])Nc1cc(Nc2cc(Cl)cn(-c3ccccn3)c2=O)nn2c(cnc12)C(=O)N[C@@H]1C[C@@H]1F

InChI Key InChIKey=WXJMDOFJXBVULD-FIBGUPNXSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50632574   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632574(CHEMBL5401457)
Affinity DataEC50: <10nMAssay Description:Inhibition of JAK2/TYK2 in HEK293T cells co-expressing luciferase gene under control of ISRE assessed as reduction in IFNalpha expression incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632574(CHEMBL5401457)
Affinity DataEC50: <1nMAssay Description:Inhibition of JAK2/TYK2 in HEK-Blue IL-23 cells assessed as reduction in SEAP reporter gene expression incubated for 21 hrs by Quanti-blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632574(CHEMBL5401457)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of JAK2 in human TF-1 cells assessed as reduction of STAT5 phosphorylation by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed