BDBM50632498 CHEMBL5415748

SMILES CN1CCC2(CC1)CN(CCO2)c1ncnc2[nH]c(Cl)c(-c3cccc(c3)C#N)c12

InChI Key InChIKey=ZNRKSAWCBMXCBN-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50632498   

LigandPNGBDBM50632498(CHEMBL5415748)
Affinity DataIC50: 806nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as reduction in SLP76 phosphorylation pretreated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50632498(CHEMBL5415748)
Affinity DataKi:  2.90nMAssay Description:Inhibition of full length human recombinant HPK1 expressed in baculovirus-infected insect cells using 5-FAM-KRRALSSLRA-COOH peptide as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein kinase C eta type(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50632498(CHEMBL5415748)
Affinity DataKi:  7.90nMAssay Description:Inhibition of full length human recombinant PKCeta expessed in baculovirus infected insect cells using 5-FAM-RFARKGSLRQKNV-COOH peptide as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetProtein kinase C theta type(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50632498(CHEMBL5415748)
Affinity DataKi:  33nMAssay Description:Inhibition of full length C-terminal his6-tagged human recombinant PKCtheta using -FAMRFARKGSLRQKNV-COOH peptide as substrate preincubated with enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed