BDBM50631289 CHEMBL5408324

SMILES CNC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(Cc2ccc(Cl)cn2)[C@H](C)C1

InChI Key InChIKey=XSKMTIGVIQLGBB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50631289   

TargetTyrosine-protein kinase JAK2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631289(CHEMBL5408324)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631289(CHEMBL5408324)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631289(CHEMBL5408324)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant TYK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631289(CHEMBL5408324)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50631289(CHEMBL5408324)
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed