BDBM50631192 CHEMBL5422255

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCOc2ccc3c(ncnc3c2)-c2ccc(C(O)=O)c(c2)C2CCCC2)C(C)(C)C)cc1

InChI Key InChIKey=OXICLXLJBMPGTO-UHFFFAOYSA-N

Data  2 IC50  1 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50631192   

TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataIC50: 9nMAssay Description:Inhibition of CaMKK2 (161 to 449 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) star cells incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataIC50: 94nMAssay Description:Inhibition of CaMKK1 (unknown origin) incubated for 20 mins in presence of kinase tracer 236 by TR-FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataEC50:  200nMAssay Description:Inhibition of CaMKK2 in LKB1 null human A-427 cells assessed as inhibition of AMPK phosphorylation preincubated for 4 hrs followed by calcium ionopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataEC50:  290nMAssay Description:Induction of ePL tagged degradation of CaMKK2 (unknown origin) expressed in HEK292T cells incubated for 24 hrs by luminescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetElongin-C(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataKd:  130nMAssay Description:Binding affinity to N-terminal 6 his tagged VHL (54 to 213 residues)/truncated ElonginC (17 to 122 residues) /full length ElonginB (unknown origin) e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataEC50:  100nMAssay Description:Induction of degradation of CAMKK2 in human THP-1 cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataEC50:  100nMAssay Description:Induction of degradation of CAMKK2 in human VCaP cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed