BDBM50631187 CHEMBL5396413

SMILES CCOc1cc2ncnc(-c3ccc(C(O)=O)c(c3)C3CCCC3)c2cc1F

InChI Key InChIKey=JCMKBZIPVJCSSW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50631187   

TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631187(CHEMBL5396413)
Affinity DataIC50: 7nMAssay Description:Inhibition of CaMKK2 (161 to 449 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) star cells incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631187(CHEMBL5396413)
Affinity DataIC50: 54nMAssay Description:Inhibition of CaMKK1 (unknown origin) incubated for 20 mins in presence of kinase tracer 236 by TR-FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631187(CHEMBL5396413)
Affinity DataIC50: 79nMAssay Description:Inhibition of CaMKK2 in LKB1 null human A-427 cells assessed as inhibition of AMPK phosphorylation preincubated for 4 hrs followed by calcium ionopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed