BDBM50630758 CHEMBL5399022

SMILES Cc1ccc(-c2ncc3N([C@@H]4CC[C@H](O)CC4)C(=O)[C@]4(C)COCCN4c3n2)c2cc[nH]c12

InChI Key InChIKey=BYZCGCXGJTYMTH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50630758   

TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50630758(CHEMBL5399022)
Affinity DataIC50: 18nMAssay Description:Inhibition of mTORC2 in human PC-3 cells assessed as AKT phosphorylation at S473 residue in incubated for 1 hr by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50630758(CHEMBL5399022)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human GST-tagged mTOR (1360 to 2549 residues) expressed in insect cells using GFP-4E-BP1 as substrate incubated for 30 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed