BDBM50630295 CHEMBL5428867::US12110276, Compound 127

SMILES OC\C=C\C(=O)N1CC(C1)c1nn(-c2ccc(OC(F)(F)F)cc2)c2nccc(Cl)c12

InChI Key InChIKey=OTGMINCKHGEJQA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50630295   

TargetTranscriptional enhancer factor TEF-1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630295(US12110276, Compound 127 | CHEMBL5428867)
Affinity DataIC50: 8nMAssay Description:Inhibition of His-tagged TEAD1 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630295(US12110276, Compound 127 | CHEMBL5428867)
Affinity DataIC50: 17nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-5(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630295(US12110276, Compound 127 | CHEMBL5428867)
Affinity DataIC50: 13nMAssay Description:Inhibition of His-tagged TEAD3 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630295(US12110276, Compound 127 | CHEMBL5428867)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged TEAD4 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630295(US12110276, Compound 127 | CHEMBL5428867)
Affinity DataIC50: 7.90nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630295(US12110276, Compound 127 | CHEMBL5428867)
Affinity DataIC50: 17nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630295(US12110276, Compound 127 | CHEMBL5428867)
Affinity DataIC50: 13nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630295(US12110276, Compound 127 | CHEMBL5428867)
Affinity DataIC50: 3.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent