BDBM50630293 CHEMBL5403826::US12110276, Compound 86

SMILES OCc1ccnc2n(nc(CNC(=O)C#C)c12)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=OLEOCPIYXWADHD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50630293   

TargetTranscriptional enhancer factor TEF-1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged TEAD1 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-5(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 10nMAssay Description:Inhibition of His-tagged TEAD3 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged TEAD4 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 3.60nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 3.20nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 9.70nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 2.40nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent