BDBM50630291 CHEMBL5411200::US12110276, Compound 48

SMILES FC(F)(F)Oc1ccc(cc1)-n1nc(C2CN(C2)C(=O)C=C)c2c(ccnc12)C#C

InChI Key InChIKey=OTCVDVMTUCELSN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50630291   

TargetTranscriptional enhancer factor TEF-1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged TEAD1 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-5(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged TEAD3 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 9nMAssay Description:Inhibition of His-tagged TEAD4 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranscriptional enhancer factor TEF-1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 3.5nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 2.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 4.80nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 0.880nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In DepthDetails
US Patent