BDBM50629205 CHEMBL5394931

SMILES O[C@@H](CCNc1cc(c(=O)[nH]n1)C(F)(F)F)C(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F

InChI Key InChIKey=GWVXXGYYIFRBAL-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50629205   

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50629205(CHEMBL5394931)
Affinity DataIC50: 0.141nMAssay Description:Displacement of biotinylated RBN011147 probe from PARP7 (unknown origin) preincubated for 1 hr followed by probe addition and measured after 1.5 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50629205(CHEMBL5394931)
Affinity DataEC50:  21nMAssay Description:Inhibition of PARP7 in human NCI-H1373 cells assessed as increase in STAT1 phosphorylation at Tyr701 residue incubated for 48 hrs by LANCE Ultra TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed