BDBM50624746 CHEMBL5399261

SMILES Oc1ccc2cc(ccc2c1)-c1ccc(NC(=O)CCc2ccccc2)cc1

InChI Key InChIKey=FVUKKANXXJOLKI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50624746   

TargetDNA topoisomerase 2-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624746(CHEMBL5399261)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of human topoisomerase 2-alpha using pBR322 DNA as substrate incubated for 30 mins in presence of 0.5 to 5 mM ATP (Rvb = 3.4 microM)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624746(CHEMBL5399261)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human topoisomerase 2-alpha assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis met...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-beta(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50624746(CHEMBL5399261)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of human topoisomerase 2-beta assessed as reduction in relaxation of pBR322 DNA measured after 30 mins by agarose gel electrophoresis meth...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed