BDBM50622927 CHEMBL5430412::US12122750, Example 2

SMILES CN(C(=O)N1CCC(CC(=O)N(c2ccccc2)c2ccccc2)(CC1)C(O)=O)c1ccc(F)cc1

InChI Key InChIKey=QVMCAEQAKIACEJ-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50622927   

TargetType-2 angiotensin II receptor(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50622927(CHEMBL5430412 | US12122750, Example 2)
Affinity DataKi:  0.352nMAssay Description:Displacement of ([125I]-Tyr4)-Angiotensin-II from recombinant human AT2R by gamma scintillation counter assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetType-2 angiotensin II receptor(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50622927(CHEMBL5430412 | US12122750, Example 2)
Affinity DataKi:  0.352nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent

TargetType-1 angiotensin II receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM50622927(CHEMBL5430412 | US12122750, Example 2)
Affinity DataKi:  3.73E+4nMAssay Description:Receptor binding affinities (Ki) were determined from a competitive radioligand binding assay with human recombinant ([125I]-Tyr4)-Angiotensin-II (22...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent