BDBM50622481 CHEMBL5428013

SMILES FC(F)(F)COc1ncncc1NC(=O)c1ccnc(Nc2ccc(cc2)C#N)n1

InChI Key InChIKey=GTWJSUYVWGBQFX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50622481   

TargetGlycogen synthase kinase-3 beta(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM50622481(CHEMBL5428013)
Affinity DataIC50: 0.740nMAssay Description:Displacement of FL-KRREILSRRP[ps]ERYR-NH2 from human recombinant N-terminal His6-tagged GSK-3-beta (14 to 306 residues) H355L mutant expressed in bac...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM50622481(CHEMBL5428013)
Affinity DataIC50: 0.150nMAssay Description:Displacement of FL-KRREILSRRP[ps]ERYR-NH2 from human recombinant full length GST-tagged GSK-3-alpha expressed in insect cells incubated for 20 hrs by...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Biocon-Bristol Myers Squibb Research and Development Center

Curated by ChEMBL
LigandPNGBDBM50622481(CHEMBL5428013)
Affinity DataIC50: 22nMAssay Description:Inhibition of GSK-3 in human U2OS cells transfected with beta-catenin GFP and 4R1N tau plasmid assessed as inhibition of Tau phosphorylation at Ser39...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed