BDBM50621796 CHEMBL5396715

SMILES O=C(C1CC1)N1CCC[C@@H](C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2c1

InChI Key InChIKey=MIFPZJRPCSILQA-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50621796   

TargetMitogen-activated protein kinase 8(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 298nMAssay Description:Inhibition of JNK1 (unknown origin) using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 9(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 144nMAssay Description:Inhibition of JNK2 (unknown origin) using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 10(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK3 (unknown origin) using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 10(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 1nMAssay Description:Inhibition of human JNK3 incubated for 40 mins in presence of ATP and [gamma33P-ATP] by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 8(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 298nMAssay Description:Inhibition of human JNK1 incubated for 40 mins in presence of ATP and [gamma33P-ATP] by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 9(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 144nMAssay Description:Inhibition of human JNK2 incubated for 40 mins in presence of ATP and [gamma33P-ATP] by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 5.78E+3nMAssay Description:Inhibition of human GSK3alpha assessed as incorporation of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of human GSK3beta assessed as incorporation of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of MKK6 (unknown origin) assessed as incorporation of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetMAPK/MAK/MRK overlapping kinase(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of MOK (unknown origin) assessed as incorporation of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 14(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 310nMAssay Description:Inhibition of human SAPK2a assessed as incorporation of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 11(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 280nMAssay Description:Inhibition of human SAPK2b assessed as incorporation of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 970nMAssay Description:Inhibition of MKK4 (unknown origin) assessed as incorporation of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 8(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 860nMAssay Description:Inhibition of human JNK1alpha1 assessed as incorporation of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 9(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50621796(CHEMBL5396715)
Affinity DataIC50: 340nMAssay Description:Inhibition of human JNK2alpha1 assessed as incorporation of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed