BDBM50621264 CHEMBL5417444

SMILES COc1cc(cc(OC(F)F)c1C(=O)NC1CC1)-n1cnc2cc(ccc12)-c1cnn(C)c1

InChI Key InChIKey=PFTXFNSHFZLJNT-UHFFFAOYSA-N

Data  26 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50621264   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 616nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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In Depth
Date in BDB:
12/17/2024
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TargetSerine/threonine-protein kinase SIK3(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 0.600nMAssay Description:Inhibition of full length SIK3 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In Depth
Date in BDB:
12/16/2024
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TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 0.700nMAssay Description:Inhibition of full length human SIK2 using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/16/2024
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TargetSerine/threonine-protein kinase SIK1(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal GST-tagged wild type human SIK1 (1 to 783 residues) expressed in baculovirus-infected Sf21 cells using AMARA peptide as subs...More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/16/2024
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TargetTyrosine-protein kinase HCK(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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In Depth
Date in BDB:
12/17/2024
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TargetMast/stem cell growth factor receptor Kit(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of KIT (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
12/17/2024
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TargetSerine/threonine-protein kinase receptor R3(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of ACVRL1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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In Depth
Date in BDB:
12/17/2024
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TargetCyclin-G-associated kinase(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of GAK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
12/17/2024
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TargetBone morphogenetic protein receptor type-1B(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of BMPR1B (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
12/17/2024
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TargetSerine/threonine-protein kinase NLK(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of NLK (unknown origin)More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
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Date in BDB:
12/17/2024
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TargetActivin receptor type-1(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 992nMAssay Description:Inhibition of ACVR1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
12/17/2024
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TargetActivin receptor type-2A(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 860nMAssay Description:Inhibition of ACVR2A (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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In Depth
Date in BDB:
12/17/2024
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TargetTyrosine-protein kinase Blk(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 730nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
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In Depth
Date in BDB:
12/17/2024
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TargetSerine/threonine-protein kinase SIK1(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 2nMAssay Description:Inhibition of SIK1 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/17/2024
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TargetTyrosine-protein kinase Yes(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 598nMAssay Description:Inhibition of YES1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
12/17/2024
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TargetTyrosine-protein kinase ABL2(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 493nMAssay Description:Inhibition of ABL2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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In Depth
Date in BDB:
12/17/2024
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TargetTyrosine-protein kinase Fyn(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 447nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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In Depth
Date in BDB:
12/17/2024
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TargetTyrosine-protein kinase Lck(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 385nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/17/2024
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TargetTyrosine-protein kinase ABL1(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 325nMAssay Description:Inhibition of ABL1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/17/2024
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TargetTyrosine-protein kinase Lyn(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 272nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
12/17/2024
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TargetMitogen-activated protein kinase kinase kinase 20(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 103nMAssay Description:Inhibition of MAP3K20 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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In Depth
Date in BDB:
12/17/2024
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TargetLIM domain kinase 1(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 67nMAssay Description:Inhibition of LIMK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
12/17/2024
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TargetEpithelial discoidin domain-containing receptor 1(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 57nMAssay Description:Inhibition of DDR1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/17/2024
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TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Inhibition of RIPK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In Depth
Date in BDB:
12/17/2024
Entry Details
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TargetSerine/threonine-protein kinase SIK3(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 0.600nMAssay Description:Inhibition of human SIK3 isoform 1 (59 to 1321 residues) expressed in Sf9 insect cells using AMARA peptide as substrate incubated for 120 mins in pre...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In Depth
Date in BDB:
12/17/2024
Entry Details
Copy Entry DOIPubMed
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TargetSerine/threonine-protein kinase SIK2(Human)
Galapagos

Curated by ChEMBL

LigandBDBM50621264(CHEMBL5417444)Copy SMILESCopy InChI

Affinity DataIC50: 0.700nMAssay Description:Inhibition of SIK2 (unknown origin) using AMARA peptide as substrate incubated for 120 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

Ligand InfoSimilars

In Depth
Date in BDB:
12/17/2024
Entry Details
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