BDBM50619107 CHEMBL5432626

SMILES CC(C)n1cc(cn1)-c1nc(Nc2ccc(CNC(=O)C=C)cc2)ncc1C

InChI Key InChIKey=AAZQIXVGVZXCAD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50619107   

TargetTyrosine-protein kinase JAK2(Human)
The Affiliated Hospital of Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50619107(CHEMBL5432626)
Affinity DataIC50: 245nMAssay Description:Inhibition of JAK2 V617F mutant in human SET2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Mouse)
The Affiliated Hospital of Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50619107(CHEMBL5432626)
Affinity DataIC50: 129nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
The Affiliated Hospital of Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50619107(CHEMBL5432626)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of FLT3 in human MOLM-13 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
The Affiliated Hospital of Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50619107(CHEMBL5432626)
Affinity DataIC50: 106nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
The Affiliated Hospital of Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50619107(CHEMBL5432626)
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
The Affiliated Hospital of Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50619107(CHEMBL5432626)
Affinity DataIC50: 208nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
The Affiliated Hospital of Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50619107(CHEMBL5432626)
Affinity DataIC50: 77nMAssay Description:Inhibition of TYK2 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
The Affiliated Hospital of Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50619107(CHEMBL5432626)
Affinity DataIC50: 320nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed