BDBM50617852 CHEMBL5400665

SMILES O=C1OC(CCNCC2Cc3cccc(C#N)c3C2)CN1c1ccc2OCC(=O)Nc2n1

InChI Key InChIKey=RXANXGVEULKMLY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50617852   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Roche Pharma Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50617852(CHEMBL5400665)
Affinity DataIC50: 21nMAssay Description:Inhibition of Escherichia coli DNA gyrase ATPase activity incubated for 80 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Roche Pharma Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50617852(CHEMBL5400665)
Affinity DataIC50: 100nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoiling activity using relaxed pBR322 DNA as substrate preincubated for 5 mins followed by enzyme addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Roche Pharma Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50617852(CHEMBL5400665)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha decatenation activity using kDNA as substrate preincubated for 5 mins followed by enzyme addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Roche Pharma Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50617852(CHEMBL5400665)
Affinity DataIC50: 900nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated path clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Roche Pharma Research & Early Development

Curated by ChEMBL
LigandPNGBDBM50617852(CHEMBL5400665)
Affinity DataIC50: 21nMAssay Description:Inhibition of Escherichia coli DNA gyrase incubated for 80 mins by Transcreener ADP2 FI assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed