BDBM50617302 CHEMBL5085558

SMILES CN(c1ncccc1CNc1ccnc(n1)-c1nc2c(F)c(Cl)ccc2[nH]1)S(C)(=O)=O

InChI Key InChIKey=WBFJDKLBAAHKIL-UHFFFAOYSA-N

Data  11 IC50  1 Kd  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50617302   

TargetSRSF protein kinase 3(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human SRPK3 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DYRK3 using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DYRK2 using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DYRK1B using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DYRK1A using RRRFRPASPLRGPPK as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CLK4 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Homo sapiens)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CLK3 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CLK2 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CLK1 using myelin basic protein as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 1(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 3nMAssay Description:Inhibition of human SRPK1 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 3(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataEC50:  20nMAssay Description:Inhibition of N-terminal nLuc-fused SRPK3 (unknown origin) transfected in lysed HEK293T cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 1(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataEC50:  44nMAssay Description:Inhibition of C-terminal nLuc-fused SRPK1 (unknown origin) transfected in lysed HEK293T cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 1(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataKd:  145nMAssay Description:Binding affinity to SRPK1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataEC50:  149nMAssay Description:Inhibition of N-terminal nLuc-fused SRPK2 (unknown origin) transfected in lysed HEK293T cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 3(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataEC50:  40nMAssay Description:Inhibition of N-terminal nLuc-fused SRPK3 (unknown origin) transfected in intact HEK293T cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 1(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataEC50:  98nMAssay Description:Inhibition of C-terminal nLuc-fused SRPK1 (unknown origin) transfected in intact HEK293T cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)
Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 80nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed