BDBM50617126 CHEMBL5413843

SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CC[C@@H](C1)Nc1nccc(n1)-c1c(nn2ccccc12)-c1ccccc1

InChI Key InChIKey=LHIXDFRNBOEPTF-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50617126   

TargetMitogen-activated protein kinase 8(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617126(CHEMBL5413843)
Affinity DataIC50: 166nMAssay Description:Inhibition of His-tagged human recombinant JNK1 expressed in insect cells incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617126(CHEMBL5413843)
Affinity DataIC50: 5nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617126(CHEMBL5413843)
Affinity DataKd:  270nMAssay Description:Binding affinity to wild type partial length human PIKFYVE (F1512 to C2098 residues) expressed in mammalian expression system by KdELECT kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50617126(CHEMBL5413843)
Affinity DataIC50: 292nMAssay Description:Inhibition of Nano-Luc fused PIKFYVE (unknown origin) expressed in HEK293T cells pretreated for 3 hrs followed by K8-tarcer addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed