BDBM50616840 CHEMBL5415586

SMILES COc1ccccc1Nc1cc(Nc2cccc(C)n2)ncc1C(N)=O

InChI Key InChIKey=GXLRNOIQEDNDKT-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50616840   

TargetTyrosine-protein kinase JAK1(Human)
Novartis

Curated by ChEMBL
LigandPNGBDBM50616840(CHEMBL5415586)
Affinity DataIC50: 14nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin) using FITC-Ahx-KKSRGDYMTMQIG-NH2 peptide as substrate incubated for 60 mins in the presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis

Curated by ChEMBL
LigandPNGBDBM50616840(CHEMBL5415586)
Affinity DataIC50: 14nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis

Curated by ChEMBL
LigandPNGBDBM50616840(CHEMBL5415586)
Affinity DataIC50: 18nMAssay Description:Inhibition of JAK3 JH1 domain (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis

Curated by ChEMBL
LigandPNGBDBM50616840(CHEMBL5415586)
Affinity DataIC50: 15nMAssay Description:Inhibition of TYK2 (unknown origin) by caliper technologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50616840(CHEMBL5415586)
Affinity DataIC50: 85nMAssay Description:Inhibition of JAK1/JAK3 in human M07E cells assessed as reduction of IL-15 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50616840(CHEMBL5415586)
Affinity DataIC50: 33nMAssay Description:Inhibition of JAK1/TYK2 in human M07E cells assessed as reduction of IFN alpha stimulated STAT phosphorylation preincubated for 30 mins followed by I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50616840(CHEMBL5415586)
Affinity DataIC50: 994nMAssay Description:Inhibition of JAK1/JAK3 in human blood assessed as reduction of IL-2 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-2 stimul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed