BDBM50616185 CHEMBL5438086

SMILES COc1ccc(cc1)C1(CCC(F)(F)CC1)C(=O)N1C[C@H](F)C[C@@H]1C(=O)Nc1ccc2[nH]ncc2n1

InChI Key InChIKey=UCKDTCZSOLMOMQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50616185   

TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant human full length EP300 assessed as inhibition of H4 peptide acetylation using biotinylated H4 peptide as substrate in pres...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 54nMAssay Description:Inhibition of EP300 in human LK2 cells assessed as reduction in intracellular H3K27 acetylation incubated for 3 hrs by chemiluminescence based ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCREB-binding protein(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 1nMAssay Description:Inhibition of CBP (unknown origin) biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr in presence of acetyl-coA by AlphaLISA ass...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT5(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of TIP60 (unknown origin) biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr in presence of acetyl-coA by AlphaLISA a...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT7(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MYST2 (unknown origin) biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr in presence of acetyl-coA by AlphaLISA a...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT6B(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MYST4 (unknown origin) biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr in presence of acetyl-coA by AlphaLISA a...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PCAF (unknown origin) biotinylated H3 (1 to 21)-GGK peptide as substrate incubated for 1 hr in presence of acetyl-coA by AlphaLISA assa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Daiichi Sankyo Co.

Curated by ChEMBL
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GCN5 (unknown origin) biotinylated H3 (1 to 21)-GGK peptide as substrate incubated for 1 hr in presence of acetyl-coA by AlphaLISA assa...More data for this Ligand-Target Pair
In DepthDetails
PubMed