BDBM50615412 CHEMBL5273254

SMILES [H][C@@]12CC[C@H](N3CCCC3)[C@@]1(C)CC[C@]1([H])c3ccc(OCCCCN4CCCC4)cc3CC[C@@]21[H]

InChI Key InChIKey=BBPNHCYTOLQTJQ-UHFFFAOYSA-N

Data  2 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50615412   

TargetHistamine H3 receptor(Human)
Chemical Works of Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50615412(CHEMBL5273254)
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of imetit-stimulation ERK1/2 phosphorylation by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetHistamine H3 receptor(Human)
Chemical Works of Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50615412(CHEMBL5273254)
Affinity DataEC50:  0.700nMAssay Description:Inverse agonist activity at recombinant human histamine H3 receptor expressed in CHO-K1 cells preincubated for 10 mins followed by [35S]GTPgammaS add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetHistamine H3 receptor(Human)
Chemical Works of Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50615412(CHEMBL5273254)
Affinity DataKi:  0.800nMAssay Description:Displacement of N-alpha-[methyl-3H]-methylhistamine dihydrochloride from recombinant human histamine H3 receptor expressed in CHO-K1 cells assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetHistamine H3 receptor(Rat)
Chemical Works of Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50615412(CHEMBL5273254)
Affinity DataKi:  25nMAssay Description:Displacement of N-alpha-[methyl-3H]-methylhistamine dihydrochloride from Sprague-Dawley rat brain membrane histamine H3 receptor assessed as inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed