BDBM50614509 CHEMBL5286909

SMILES [H][C@@]12CC[C@@]([H])(N1c1ncc3[nH]nc(-c4cnn(c4)C4CCC4)c3n1)C(=O)N(C)C2

InChI Key InChIKey=OXJWXQVCCWDQJS-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50614509   

TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant N-terminal His-Avi-tag human FGFR3 (447 to 761 residues) expressed in Sf9 infected baculovirus expression system using biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human wild type FGFR1 (399 to 820 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 157nMAssay Description:Inhibition of recombinant human FGFR4 (460 to 802 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human FGFR2 (400 to 821 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 477nMAssay Description:Inhibition of recombinant human ALK2 (147 to end residues) expressed in Sf9 infected baculovirus expression system using TRF0130 as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Mouse)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 16nMAssay Description:Inhibition of FGFR3 phosphorylation in mouse BaF3 cells incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 24nMAssay Description:Inhibition of FGFR2 in human KATOIII cells incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50614509(CHEMBL5286909)
Affinity DataIC50: 184nMAssay Description:Inhibition of KDR (unknown origin) using peptide substrate incubated for 90 mins in presence of ATP by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed