BDBM50614501 CHEMBL5290074

SMILES CN1CC2CCC(C2c2ncc3[nH]nc(-c4cnn(C)c4)c3n2)C1=O

InChI Key InChIKey=NRBSFHSUWBAYCI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50614501   

TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614501(CHEMBL5290074)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of recombinant N-terminal His-Avi-tag human FGFR3 (447 to 761 residues) expressed in Sf9 infected baculovirus expression system using biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614501(CHEMBL5290074)
Affinity DataIC50: 89nMAssay Description:Inhibition of recombinant human wild type FGFR1 (399 to 820 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614501(CHEMBL5290074)
Affinity DataIC50: 351nMAssay Description:Inhibition of recombinant human FGFR4 (460 to 802 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614501(CHEMBL5290074)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant human FGFR2 (400 to 821 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614501(CHEMBL5290074)
Affinity DataIC50: 930nMAssay Description:Inhibition of recombinant human ALK2 (147 to end residues) expressed in Sf9 infected baculovirus expression system using TRF0130 as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Mouse)
Incyte

Curated by ChEMBL
LigandPNGBDBM50614501(CHEMBL5290074)
Affinity DataIC50: 70nMAssay Description:Inhibition of FGFR3 phosphorylation in mouse BaF3 cells incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed