BDBM50613394 CHEMBL5278465

SMILES Clc1ccc(cc1)-c1ccncc1NC(=O)c1ccnc(NC(=O)C2CC2)c1

InChI Key InChIKey=OYNBEDDKSIPEQC-UHFFFAOYSA-N

Data  54 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 54 hits for monomerid = 50613394   

TargetTau-tubulin kinase 2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of TTBK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of cKIT (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of wild type ABL (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK5/p25 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TYK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JNK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of LCK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCasein kinase II subunit alpha'(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CK2A2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of IRAK4 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Aurora-B (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of BTK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAurora kinase A(Mouse)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mouse Aurora kinase A by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTau-tubulin kinase 1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of TTBK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMAP/microtubule affinity-regulating kinase 4(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MARK4 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMAP/microtubule affinity-regulating kinase 3(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MARK3 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MARK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase MARK1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MARK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of FYN (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TNIK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TEC (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ITK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 200nMAssay Description:Inhibition of GSK-3beta (unknown origin) assessed as decrease in tau phosphorylation by high content cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of GST tagged GSK-3beta (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ACK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 200nMAssay Description:Inhibition of GSK-3 in human U2OS cells transfected with beta-catenin GFP and 4R1N tau plasmid assessed as inhibition of Tau phosphorylation at Ser39...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PIM1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetProtein kinase C theta type(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKC theta type (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of RSK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SYK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of FMS (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ROCK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ROCK2 mutant (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Srms(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SRMS (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TRKA (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TRKB (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TYK2 (0 to 887 residues) (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.90nMAssay Description:Displacement of FL-KRREILSRRP[ps]ERYR-NH2 from human recombinant N-terminal His6-tagged GSK-3-beta (14 to 306 residues) H355L mutant expressed in bac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CK1D (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 33(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of STK33 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ZAP70 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase CSK(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CSK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of BMX (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of IRAK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of IKK2 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50613394(CHEMBL5278465)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK1 (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
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