BDBM50611758 CHEMBL5273533

SMILES C[C@@H]1CCN(C[C@@H]1n1ccc2cnc3[nH]cc(C#N)c3c12)C(=O)CC#N

InChI Key InChIKey=PFZVRMSUBHGEID-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50611758   

TargetInsulin-like growth factor 1 receptor(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 11(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of P38beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MAPKAPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 1(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MAP3K1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IKKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CHKdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBone morphogenetic protein receptor type-1A(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BMPR1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAngiopoietin-1 receptor(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of TIE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EphA2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase CSK(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50611758(CHEMBL5273533)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed