BDBM50607768 CHEMBL5219602

SMILES C[C@@H]1c2ccc(cc2C(=CN(C1=O)C)c3cnn(c3)C)[C@H](CO)O

InChI Key InChIKey=CJVJSGBELMMESS-UHFFFAOYSA-N

Data  5 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50607768   

TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50607768(CHEMBL5219602)
Affinity DataIC50: 63nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50607768(CHEMBL5219602)
Affinity DataIC50: 32nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetC-C motif chemokine 2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50607768(CHEMBL5219602)
Affinity DataIC50: 40nMAssay Description:Inhibition of MCP-1 in LPS-stimulated human whole blood incubate for 24 hrs by immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50607768(CHEMBL5219602)
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM50607768(CHEMBL5219602)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM50607768(CHEMBL5219602)
Affinity DataKd:  1.26E+3nMAssay Description:Binding affinity to human TRIM24 bromodomain by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed