BDBM50606737 CHEMBL5218727::US11731973, Example 5

SMILES CC(C)C[C@H](C)n1nc(-c2ccc3oc(N)nc3c2F)c2c(N)nc(N)nc12

InChI Key InChIKey=PZLDVTRVPWMLFG-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50606737   

TargetTarget of rapamycin complex subunit LST8(Human)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606737(CHEMBL5218727 | US11731973, Example 5)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of mTORC1 in human A-431 cells assessed as phosphorylated S6RP level incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606737(CHEMBL5218727 | US11731973, Example 5)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of mTORC2 in human A-431 cells assessed as phosphorylated AKT level incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50606737(CHEMBL5218727 | US11731973, Example 5)
Affinity DataKi:  0.400nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2023
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50606737(CHEMBL5218727 | US11731973, Example 5)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed