BDBM50606174 CHEMBL5200584

SMILES [H][C@@]12CN(c3cc(OC)c(cc3NC(=O)C#CC)-c3cc4n(CC)c(=O)c(cc4cn3)-c3c(Cl)c(OC)cc(OC)c3Cl)[C@@]([H])(CO1)C2

InChI Key InChIKey=VDIDNMGZRIMBKL-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50606174   

TargetFibroblast growth factor receptor 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 3.07E+3nMAssay Description:Inhibition of wild type FGFR1 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of FGFR4 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild type FGFR2 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild type FGFR3 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 89nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin) at 1 uM using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 9.22E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using Midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50606174(CHEMBL5200584)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of hERG channel assessed as prolongation of QT interval by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed