BDBM50605644 CHEMBL5209093::US11981669, Comparative Example 3

SMILES OC(=O)CNC(=O)c1nc(Br)c2cc(Oc3ccccc3)ccc2c1O

InChI Key InChIKey=MOOCHEISIIMJAU-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50605644   

TargetThyroid hormone receptor alpha(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50605644(CHEMBL5209093 | US11981669, Comparative Example 3)
Affinity DataEC50:  15nMAssay Description:Agonist activity at wild type human TR alpha LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of N-terminal biotinylated coactivato...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetThyroid hormone receptor beta(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50605644(CHEMBL5209093 | US11981669, Comparative Example 3)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetEgl nine homolog 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50605644(CHEMBL5209093 | US11981669, Comparative Example 3)
Affinity DataIC50: 58nMAssay Description:Inhibition of PHD2 (unknown origin) incubated for 15 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProlyl hydroxylase EGLN2(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM50605644(CHEMBL5209093 | US11981669, Comparative Example 3)
Affinity DataIC50: 452nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
Go to US Patent

TargetEgl nine homolog 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50605644(CHEMBL5209093 | US11981669, Comparative Example 3)
Affinity DataIC50: 951nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
Go to US Patent

TargetProlyl hydroxylase EGLN3(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM50605644(CHEMBL5209093 | US11981669, Comparative Example 3)
Affinity DataIC50: 544nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
Go to US Patent