BDBM50605448 CHEMBL5179617

SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2nccc(Sc3cnc(cn3)N3CCC4(CO[C@@H](C)[C@H]4N)CC3)c2Cl)ncc1F

InChI Key InChIKey=ZDEBEWQYXJZQRS-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50605448   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of SHP2 (unknown origin) using DiFMUP as substrate incubated for 60 mins followed by substrate addition for 30 mins by microplate reader m...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK4/Cyclin D3 expressed in Sf9 insect cells using 5-FAM-IPTSPITTTYFFFKKK as substr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of SHP2 PTP domain (unknown origin) using DiFMUP as substrate preincubated for 20 mins followed by substrate addition and measured for 2 h...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of SHP1 (unknown origin) using DiFMUP as substrate preincubated for 20 mins followed by substrate addition and measured for 2 hrs by fluor...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCDK2/Cyclin-E2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 464nMAssay Description:Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK2/Cyclin E2 expressed in Sf9 insect cells incubated for 20 mins followed by [33P...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK3/Cyclin E expressed in Sf9 insect cells incubated for 20 mins followed by [33P]...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK4/Cyclin D3 expressed in Sf9 insect cells incubated for 20 mins followed by [33P...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 540nMAssay Description:Inhibition of recombinant full length N-terminal GST/His6-fusion tagged human CDK5/P25 expressed in Sf9 insect cells incubated for 20 mins followed b...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 634nMAssay Description:Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK6/Cyclin D3 expressed in Sf9 insect cells incubated for 20 mins followed by [33P...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 968nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin) incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 12(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 697nMAssay Description:Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK12/Cyclin K expressed in Sf9 insect cells incubated for 20 mins followed by [33P...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 13/Cyclin-K(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50605448(CHEMBL5179617)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK13/Cyclin K expressed in Sf9 insect cells incubated for 20 mins followed by [33P...More data for this Ligand-Target Pair
In DepthDetails
PubMed