BDBM50604466 CHEMBL5201766
SMILES CCn1nc(C)cc1C(=O)Nc1nc2cc(cc(OC)c2n1C\C=C\Cn1c(NC(=O)c2cc(C)nn2CC)nc2cc(cc(OCCCNC(=O)OC(C)(C)C)c12)C(N)=O)C(N)=O
InChI Key InChIKey=PIYRZERUGHECIE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50604466
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.0623nMAssay Description:Binding affinity to recombinant human His-tagged STING by measuring fluorescent signals in the presence of d2 labelled STING wild type ligand by HTRF...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataEC50: 0.354nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as cocktail probe substrate preincubated for 5 mins followed by NADPH addition and me...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 in human liver microsomes tolbutamide as cocktail probe substrate preincubated for 5 mins followed by NADPH addition and measure...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as cocktail probe substrate preincubated for 5 mins followed by NADPH addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as cocktail probe substrate preincubated for 5 mins followed by NADPH addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using sorafenib as cocktail probe substrate preincubated for 5 mins followed by NADPH addition and mea...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of hERG by patch clamp assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataEC50: 2nMAssay Description:Activation of STING mediated immune response in human THP-1 cells assessed as induction of IFNbeta secretion measured after 24 hrs by ELISAMore data for this Ligand-Target Pair