BDBM50603089 CHEMBL5194720

SMILES C[C@H]1C[C@@H](Nc2ccc(Cl)cn2)c2cc(ccc2N1C(C)=O)C(N)=O

InChI Key InChIKey=ARPOIMNRYOLMEZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50603089   

TargetBromodomain-containing protein 4(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50603089(CHEMBL5194720)
Affinity DataIC50: 251nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) incubated for 30 mins in presence of fluorescent ligand by TR-FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50603089(CHEMBL5194720)
Affinity DataIC50: 79nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) incubated for 30 mins in presence of fluorescent ligand by TR-FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetC-C motif chemokine 2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50603089(CHEMBL5194720)
Affinity DataIC50: 398nMAssay Description:Inhibition of MCP-1 in LPS-stimulated human whole blood incubate for 24 hrs by immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50603089(CHEMBL5194720)
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50603089(CHEMBL5194720)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed