BDBM50599250 CHEMBL5178837

SMILES Cc1cc2ncccc2cc1Nc1ncc2n(C)c(=O)n([C@@H]3CNC[C@@H]3F)c2n1

InChI Key InChIKey=VHGGSMHLKWIQAF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50599250   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599250(CHEMBL5178837)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-induced autophosphorylation at S2056 residue preincubated for 1 hr foll...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599250(CHEMBL5178837)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50599250(CHEMBL5178837)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of hERG expressed in CHO cells by electrophysiological assay based automated patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed