BDBM50599236 CHEMBL5186637::US11884671, Example 44

SMILES CN1CCC(CC1)n1c2nc(Nc3cc4cccnc4cc3C)ncc2n(C)c1=O

InChI Key InChIKey=FDMMYUOTNSORRO-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50599236   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599236(CHEMBL5186637 | US11884671, Example 44)
Affinity DataIC50: 210nMAssay Description:Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-induced autophosphorylation at S2056 residue preincubated for 1 hr foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599236(CHEMBL5186637 | US11884671, Example 44)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50599236(CHEMBL5186637 | US11884671, Example 44)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of hERG expressed in CHO cells by electrophysiological assay based automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50599236(CHEMBL5186637 | US11884671, Example 44)
Affinity DataIC50: 3.16nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM50599236(CHEMBL5186637 | US11884671, Example 44)
Affinity DataIC50: 7.94E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent
LigandPNGBDBM50599236(CHEMBL5186637 | US11884671, Example 44)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK1: The 2×JAK/Tyr 06 (ThermoFisher Scientific proprietary) mixture was prepared in 50 mM HEPES pH 6.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, 0.02%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent
LigandPNGBDBM50599236(CHEMBL5186637 | US11884671, Example 44)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK2: The 2×JAK2/Tyr 06 (ThermoFisher Scientific proprietary) mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

US Patent
LigandPNGBDBM50599236(CHEMBL5186637 | US11884671, Example 44)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK3: The 2×JAK3/Tyr 06 (ThermoFisher Scientific proprietary) mixture was prepared in 50 mM HEPES pH 7.5. 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astrazeneca

US Patent
LigandPNGBDBM50599236(CHEMBL5186637 | US11884671, Example 44)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Astrazeneca

US Patent
LigandPNGBDBM50599236(CHEMBL5186637 | US11884671, Example 44)
Affinity DataIC50: 1.00E+4nMAssay Description:Aurora B (AurB): The 2×AURKB (Aurora B)/Ser/Thr 01 (ThermoFisher Scientific proprietary) mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2024
Entry Details
Go to US Patent