BDBM50598847 CHEMBL5200849::US20240207300, Compound 54

SMILES Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc(cnc12)N1CCOCC1

InChI Key InChIKey=FKGXPIQMSCNIPK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50598847   

TargetCytochrome P450 2D6(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598847(CHEMBL5200849 | US20240207300, Compound 54)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598847(CHEMBL5200849 | US20240207300, Compound 54)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598847(CHEMBL5200849 | US20240207300, Compound 54)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50598847(CHEMBL5200849 | US20240207300, Compound 54)
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMyelin transcription factor 1(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM50598847(CHEMBL5200849 | US20240207300, Compound 54)
Affinity DataIC50: 10nMAssay Description:Detection of Myt1 kinase activity utilized a recombinant human Myt1 kinase assay measuring the hydrolysis of ATP using a commercially available ADP-G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent