BDBM50598829 CHEMBL5203261

SMILES Cc1ccc(O)cc1-n1c(N)c(C(N)=O)c2cc3ccccc3nc12

InChI Key InChIKey=CCLATZMUQLEESJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50598829   

TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598829(CHEMBL5203261)
Affinity DataIC50: 7nMAssay Description:Inhibition of full length Nano-luc fused EPHB3 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50598829(CHEMBL5203261)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50598829(CHEMBL5203261)
Affinity DataIC50: 360nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
In DepthDetails
PubMed