BDBM50598463 CHEMBL5195325

SMILES [H][C@]12CN([C@H](C(=O)N[C@@H](C[C@]3([H])CCNC3=O)C=O)[C@@]1([H])C2(C)C)C(=O)COc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=RBWMYPKAPIYTJQ-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50598463   

TargetReplicase polyprotein 1ab(2019-nCoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50598463(CHEMBL5195325)
Affinity DataIC50: 15nMAssay Description:Inhibition of SARS CoV-2 main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50598463(CHEMBL5195325)
Affinity DataIC50: 15nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50598463(CHEMBL5195325)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant N-terminal SARS-CoV-2 Main protease expressed in Escherichia coli using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50598463(CHEMBL5195325)
Affinity DataIC50: 55nMAssay Description:Inhibition of His/SUMO tagged SARS-CoV-2 main protease transfected in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKME-Edans as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50598463(CHEMBL5195325)
Affinity DataEC50:  270nMAssay Description:Inhibition of eGFP-fused SARS-CoV-2 main protease transfected in HEK293T/17 cells incubated for 3 days by flow cytometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Peking University

Curated by ChEMBL
LigandPNGBDBM50598463(CHEMBL5195325)
Affinity DataIC50: 15nMAssay Description:Inhibition of SARS-CoV-2 main protease by FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed