BDBM50597264 CHEMBL5195638::US20230391758, Compound 24

SMILES CC(C)Oc1ccc(cc1-c1cc(Cl)cc2cc(oc12)C(=O)N[C@@H]1C[C@H](O)C1)C#N

InChI Key InChIKey=PVANEXPBWDHVOM-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50597264   

TargetCeramide glucosyltransferase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50597264(CHEMBL5195638 | US20230391758, Compound 24)
Affinity DataEC50:  0.0440nMAssay Description:Inhibition of GCS in human A-375 cells using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCeramide glucosyltransferase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50597264(CHEMBL5195638 | US20230391758, Compound 24)
Affinity DataEC50:  0.0440nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent