BDBM50597260 CHEMBL5182897::US20230391758, Compound 20

SMILES FCCOc1ccccc1-c1cc(Cl)cc2cc(oc12)C(=O)NC1CN2CCC1CC2

InChI Key InChIKey=KBGOFGITDNESDT-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50597260   

TargetCeramide glucosyltransferase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50597260(CHEMBL5182897 | US20230391758, Compound 20)
Affinity DataEC50:  0.0200nMAssay Description:Inhibition of GCS in human A-375 cells using C6-ceramide and UDP-glucose as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCeramide glucosyltransferase(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50597260(CHEMBL5182897 | US20230391758, Compound 20)
Affinity DataEC50:  0.0200nMAssay Description:Using Promega's UDP-Glo™ Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measur...More data for this Ligand-Target Pair
In DepthDetails
US Patent