BDBM50595814 CHEMBL5190046::US11919904, Example 9

SMILES CNS(=O)(=O)c1ccc(Nc2ncc3c(n2)N([C@@H]2CCC[C@@]2(C)O)C(=O)C32CC2)cc1

InChI Key InChIKey=XJYUSNWXKXUGGH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50595814   

LigandPNGBDBM50595814(CHEMBL5190046 | US11919904, Example 9)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged full-length CDK2/Flag-tagged cyclinE1 expressed in baculovirus expression system using eIF4E-bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50595814(CHEMBL5190046 | US11919904, Example 9)
Affinity DataIC50: 350nMAssay Description:Inhibition of CDK2 in human COV318 cells incubated for overnight in presence of human whole blood by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50595814(CHEMBL5190046 | US11919904, Example 9)
Affinity DataIC50: 746nMAssay Description:Inhibition of CDK2 in human COV318 cells incubated for overnight in presence of human whole blood by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50595814(CHEMBL5190046 | US11919904, Example 9)
Affinity DataIC50: 50nMAssay Description:CDK2/Cyclin E1 enzyme activity assays utilize full-length human CDK2 co-expressed as N-terminal GST-tagged protein with FLAG-Cyclin E1 in a baculovir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2024
Entry Details
Go to US Patent