BDBM50595813 CHEMBL5190590::US11919904, Example 15

SMILES CNS(=O)(=O)c1ccc(Nc2ncc3c(n2)N(C(=O)C32CC2)c2cc(F)ccc2Cl)cc1

InChI Key InChIKey=BTEZMGVGCNGXKJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50595813   

LigandPNGBDBM50595813(CHEMBL5190590 | US11919904, Example 15)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged full-length CDK2/Flag-tagged cyclinE1 expressed in baculovirus expression system using eIF4E-bi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50595813(CHEMBL5190590 | US11919904, Example 15)
Affinity DataIC50: 460nMAssay Description:Inhibition of CDK2 in human COV318 cells incubated for overnight in presence of human whole blood by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50595813(CHEMBL5190590 | US11919904, Example 15)
Affinity DataIC50: 50nMAssay Description:CDK2/Cyclin E1 enzyme activity assays utilize full-length human CDK2 co-expressed as N-terminal GST-tagged protein with FLAG-Cyclin E1 in a baculovir...More data for this Ligand-Target Pair
In DepthDetails
US Patent