BDBM50595744 CHEMBL5178104

SMILES [O-][N+](=O)c1cc(ccc1NC1CCCCC1)S(=O)(=O)C(Cl)(Cl)Br

InChI Key InChIKey=REBZZEDLLSTDTN-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50595744   

TargetSerine/threonine-protein kinase WNK1(Human)
The University of Texas Southwestern Medical Center At Dallas

Curated by ChEMBL
LigandPNGBDBM50595744(CHEMBL5178104)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of TEV cleavage site-fused His6-tagged WNK1 (194 to 483 residues) (unknown origin) expressed in Rosetta (DE3) cells using GST-OSR1(314 to ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase WNK1(Human)
The University of Texas Southwestern Medical Center At Dallas

Curated by ChEMBL
LigandPNGBDBM50595744(CHEMBL5178104)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of TEV cleavage site-fused His6-tagged WNK1 (194 to 483 residues) (unknown origin) expressed in Rosetta (DE3) cells using GST-OSR1(314 to ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase WNK1(Human)
The University of Texas Southwestern Medical Center At Dallas

Curated by ChEMBL
LigandPNGBDBM50595744(CHEMBL5178104)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of WNK1 in human MDA-MB-231 cells assessed as reduction in OSR1 phosphorylation measured after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)