BDBM50594972 CHEMBL5177755

SMILES COC(=O)N1CCC2(C[C@H](Nc3ncnc4n(nnc34)[C@H]3C[C@H](O)[C@H](COS(N)(=O)=O)C3)c3ccccc23)CC1

InChI Key InChIKey=FRCOPIZAOPFHPW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50594972   

TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetUbiquitin-like modifier-activating enzyme 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50: 66nMAssay Description:Inhibition of UAE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of hERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed