BDBM50593922 CHEMBL5199065

SMILES CCC(CC)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1

InChI Key InChIKey=VYKCLMALANGCDF-UHFFFAOYSA-N

Data  36 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50593922   

TargetCyclin-dependent kinase 7(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK7 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 18(Human)
Kronos Bio

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CDK18/Cyclin Y preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrs in presence of 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CDK19/Cyclin C preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrs in presence of 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK9 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 396nMAssay Description:Inhibition of CDK2 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 3(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK3 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK4 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK5 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 6(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK6 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CDK17/Cyclin Y preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrs in presence of 20 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 8(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK8 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 588nMAssay Description:Inhibition of CDK12 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 13(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 372nMAssay Description:Inhibition of CDK13 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 14(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK14 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 16(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK16 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 17(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK17 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 18(Human)
Kronos Bio

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK18 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 19(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK19 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of human CDK7/Cyclin H preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 6nMAssay Description:Inhibition of human CDK9/Cyclin T1 preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of human CDK1/Cyclin A preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 397nMAssay Description:Inhibition of human CDK2/Cyclin A preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of human CDK3/Cyclin E preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 3.13E+3nMAssay Description:Inhibition of human CDK4/Cyclin D1 preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of human CDK5/P25 preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 3.95E+3nMAssay Description:Inhibition of human CDK6/Cyclin D1 preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK9 (unknown origin) by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-C(Human)
Kronos Bio

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK8/Cyclin C preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CDK3/Cyclin E preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrs in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CDK4/Cyclin D1 preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrs in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CDK6/Cyclin D1 preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrs in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CDK7/Cyclin H preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrs in presence of 50 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CDK12/Cyclin K preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrs in presence of 30 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human CDK13/Cyclin K preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrs in presence of 5 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCyclin-Y(Human)
Kronos Bio

Curated by ChEMBL
LigandPNGBDBM50593922(CHEMBL5199065)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human CDK14/Cyclin Y preincubated for 20 mins followed by 32P-ATP addition and measured after 2 hrs in presence of 15 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed